Article

Antiviral signalling in human IPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes

2019-10-04

Abstract excerpt

Maternal immune activation increases the risk of neurodevelopmental disorders. Elevated cytokines, such as interferon-gamma (IFNγ), in offspring’s brains play a central role. IFNγ activates an antiviral cellular state, limiting viral entry and replication. In addition, IFNγ has been implicated in brain development. Here, we hypothesise that IFNγ-induced antiviral signalling contributes to molecular and cellular ph...

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Literature Corpus work: 119bd990-b1aa-5931-b18d-ce220d670cd6
DOI: 10.1101/789321

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