Article

TNF-α induces type I IFN signalling to suppress neurogenesis and recruit T cells

2025-06-24

Abstract excerpt

Adult hippocampal neurogenesis (AHN) is essential for learning, memory, and mood regulation, and its disruption is implicated in ageing, neurodegeneration, and mood disorders. However, the mechanisms linking inflammation to AHN impairment remain unclear. Here, we identify chronic tumour necrosis factor-alpha (TNF-⍺) signalling as a key driver of neurogenic dysregulation via a previously unrecognised type I interfe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c8ae963-4336-557a-af18-636c932c9105
DOI: 10.1101/2025.06.18.660440

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TNF-α induces type I IFN signalling to suppress neurogenesis and recruit T cellsDOI 10.1101/2025.06.18.660440Read

Interferon-Alpha Reduces Human Hippocampal Neurogenesis and Increases Apoptosis via Activation of Distinct STAT1-Dependent MechanismsSemantic proximity Read

Investigating How Inflammation Involving NF-κB Signaling Disrupts the Genetic Architecture of Neurons/Neural Stem Cells and Fuels NeurodegenerationSemantic proximity Read

Microglia regulate adult neurogenesis via interleukin-6 trans-signaling triggered by apoptotic progenitorsSemantic proximity Read

Type I interferon pathway in CNS homeostasis and neurological disordersSemantic proximity Read

The glia club: Validation of polarization biomarkers for human microglia (HMC3) using quantitative real time RT-qPCRSemantic proximity Read

Microglial responses to peripheral type 1 interferonSemantic proximity Read

Unique Microglial Transcriptomic Signature within the Hippocampal Neurogenic NicheSemantic proximity Read

The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes.Semantic proximity Read

Interferon-γ signaling in human iPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes.Semantic proximity Read

Stat1 is an inducible transcriptional repressor of neural stem cells self-renewal program during neuroinflammationSemantic proximity Read

The Neurogenic Potential of Astrocytes Is Regulated by Inflammatory Signals.Semantic proximity Read

Antiviral signalling in human IPSC-derived neurons recapitulates neurodevelopmental disorder phenotypesSemantic proximity Read