Article

Interferon-□ Exposure of Human iPSC-derived Neurons Alters Major Histocompatibility Complex I and Synapsin I Protein Expression

2021-12-16

Abstract excerpt

Human epidemiological data links maternal immune activation during gestation with increased risk for neurodevelopmental disorders including schizophrenia. Animal models of maternal immune activation (MIA) provide causal evidence for this association and strongly suggest that inflammatory cytokines act is a critical link between maternal infection and aberrant offspring brain and behavior development. This includes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7971cb97-006d-5a00-a851-de2b573d4c6d
DOI: 10.1101/2021.12.15.472810

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interferon-□ Exposure of Human iPSC-derived Neurons Alters Major Histocompatibility Complex I and Synapsin I Protein ExpressionDOI 10.1101/2021.12.15.472810Read

Interferon-γ signaling in human iPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes.Semantic proximity Read

Antiviral signalling in human IPSC-derived neurons recapitulates neurodevelopmental disorder phenotypesSemantic proximity Read

Attenuated transcriptional response to pro-inflammatory cytokines in schizophrenia hiPSC-derived neural progenitor cellsSemantic proximity Read

Maternal immune activation: Implications for neuropsychiatric disordersSemantic proximity Read

Induction of Toll-Like Receptor 3-Mediated Immunity during Gestation Inhibits Cortical Neurogenesis and Causes Behavioral DisturbancesSemantic proximity Read

Human genetic variation shapes the response of neurons to interferonsSemantic proximity Read

Modeling Prenatal Immune Activation in Human Brain Organoids Uncovers IL-6–Dependent Interneuron DysmaturationSemantic proximity Read

Alterations in retrotransposition, synaptic connectivity, and myelination implicated by transcriptomic changes following maternal immune activation in non-human primatesSemantic proximity Read

Maternal immune activation with high molecular weight poly (I:C) induces selective depressive-like phenotype in adult offspring.Semantic proximity Read

Maternal Immune Activation with High Molecular Weight Poly (I:C) Induces Selective Depressive-Like Phenotype in Adult OffspringSemantic proximity Read

Regulation of synaptic connectivity in schizophrenia by mutual neuron-microglia interactionSemantic proximity Read

Microglial responses to peripheral type 1 interferonSemantic proximity Read