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Article

Interferon-γ signaling in human iPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes.

Science advances - 1 Aug 2020

Warre-Cornish Katherine, Perfect Leo, Nagy Roland, Duarte Rodrigo R R, Reid Matthew J, Raval Pooja, Mueller Annett, Evans Amanda L, Couch Amalie, Ghevaert Cédric, McAlonan Grainne, Loth Eva, Murphy Declan, Powell Timothy R, Vernon Anthony C, Srivastava Deepak P, Price Jack

Abstract excerpt

Maternal immune activation increases the risk of neurodevelopmental disorders. Elevated cytokines, such as interferon-γ (IFN-γ), in offspring's brains play a central role. IFN-γ activates an antiviral cellular state, limiting viral entry and replication. Moreover, IFN-γ is implicated in brain development. We tested the hypothesis that IFN-γ signaling contributes to molecular and cellular phenotypes associated...

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Identifiers

PMID: 32875100
DOI: 10.1126/sciadv.aay9506
PMCID: PMC7438100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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