Article

Human brain organoid model of maternal immune activation identifies radial glia cells as selectively vulnerable

2022-08-10

Abstract excerpt

Maternal immune activation (MIA) during the critical windows of gestation is correlated with long- term neurodevelopmental deficits in the offspring, including increased risks for autism spectrum disorder (ASD) in humans. Interleukin 6 (IL-6) derived from the gestational parent is one of the major molecular mediators, by which MIA alters the developing brain. In this study, we established a human three-dimensional...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8c472474-4750-5012-aaa9-48635b26e433
DOI: 10.1101/2022.08.09.503336

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human brain organoid model of maternal immune activation identifies radial glia cells as selectively vulnerableDOI 10.1101/2022.08.09.503336Read

Modeling Prenatal Immune Activation in Human Brain Organoids Uncovers IL-6–Dependent Interneuron DysmaturationSemantic proximity Read

Maternal-fetal immune conflict contributes to male-specific impairments in a mouse model of neurodevelopmental disordersSemantic proximity Read

The fetal programming effect of maternal immune activation (MIA) on the offspring’s immune systemSemantic proximity Read

At the crux of maternal immune activation: Viruses, microglia, microbes, and <scp>IL‐17A</scp>Semantic proximity Read

A temporal map of maternal immune activation-induced changes reveals a shift in neurodevelopmental timing and perturbed cortical development in miceSemantic proximity Read

The Role of Immune Factors in Shaping Fetal NeurodevelopmentSemantic proximity Read

Maternal immune activation, central nervous system development and behavioral phenotypesSemantic proximity Read

The role of maternal immune activation in immunological and neurological pathogenesis of autismSemantic proximity Read

A microglia-containing cerebral organoid model to study early life immune challengesSemantic proximity Read

Maternal immune activation as an epidemiological risk factor for neurodevelopmental disorders: Considerations of timing, severity, individual differences, and sex in human and rodent studiesSemantic proximity Read

IL-17A Alters Human Cortical Development in a 3D Ex Vivo Model of Maternal Immune ActivationSemantic proximity Read

Mapping the developing human immune system across organsSemantic proximity Read