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Modeling Prenatal Immune Activation in Human Brain Organoids Uncovers IL-6–Dependent Interneuron Dysmaturation

2026-05-28

Abstract excerpt

Prenatal inflammation has been associated with an increased likelihood of the child developing neurodevelopmental conditions, such as autism spectrum disorder (ASD). Several pro-inflammatory cytokines are significantly upregulated and play critical roles during immune activation, with interleukin-6 (IL-6) being particularly prominent. However, the specific impact of elevated IL-6 levels on human neural development...

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Literature Corpus work
c8573fbb-91f9-5791-a4a0-36675b2da4cd
DOI
10.64898/2026.05.26.728058
Open publication

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Modeling Prenatal Immune Activation in Human Brain Organoids Uncovers IL-6–Dependent Interneuron DysmaturationDOI 10.64898/2026.05.26.728058
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