Article
Endogenous Retroviruses Activity as a Molecular Signature of Neurodevelopmental Disorders.
International journal of molecular sciences - 30 Nov 2019
Balestrieri Emanuela, Matteucci Claudia, Cipriani Chiara, Grelli Sandro, Ricceri Laura, Calamandrei Gemma, Vallebona Paola Sinibaldi
Abstract excerpt
Human endogenous retroviruses (HERVs) are genetic elements resulting from relics of ancestral infection of germline cells, now recognized as cofactors in the etiology of several complex diseases. Here we present a review of findings supporting the role of the abnormal HERVs activity in neurodevelopmental disorders. The derailment of brain development underlies numerous neuropsychiatric conditions, likely starting...
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