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Article

SynLeGG: analysis and visualization of multiomics data for discovery of cancer 'Achilles Heels' and gene function relationships.

Nucleic acids research - 2 Jul 2021

Wappett Mark, Harris Adam, Lubbock Alexander L R, Lobb Ian, McDade Simon, Overton Ian M

Abstract excerpt

Achilles' heel relationships arise when the status of one gene exposes a cell's vulnerability to perturbation of a second gene, such as chemical inhibition, providing therapeutic opportunities for precision oncology. SynLeGG (www.overton-lab.uk/synlegg) identifies and visualizes mutually exclusive loss signatures in 'omics data to enable discovery of genetic dependency relationships (GDRs) across 783 cancer cell...

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Identifiers

PMID: 33997893
DOI: 10.1093/nar/gkab338
PMCID: PMC8265155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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