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Long-read sequencing reveals the structural complexity of genomic integration of HPV DNA in cervical cancer cell lines

20 Feb 2024

Abstract excerpt

BACKGROUND: Cervical cancer (CC) causes more than 311,000 deaths annually worldwide. The integration of human papillomavirus (HPV) is a crucial genetic event that contributes to cervical carcinogenesis. Despite HPV DNA integration is known to disrupt the genomic architecture of both the host and viral genomes in CC, the complexity of this process remains largely unexplored. RESULTS: In this study, we conducted...

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PMID: 38378450
DOI: 10.1186/s12864-024-10101-y

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