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Article

A Proteomic Platform to Identify Off-Target Proteins Associated with Therapeutic Modalities that Induce Protein Degradation or Gene Silencing

2020-11-20

Abstract excerpt

<h4>ABSTRACT</h4> Novel modalities such as Proteolysis Targeting Chimera (PROTAC) and RNA interference (RNAi) have a mechanism of action-based potential to alter the abundance of off-target proteins. The current in vitro secondary pharmacology assays, which evaluate off-target binding or activity of small molecules, do not fully assess the off-target effects of PROTAC and are not applicable to RNAi. To address t...

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Literature Corpus work
04f50c17-2d44-5079-b183-14937c834a4d
DOI
10.1101/2020.11.18.389148
Open publication

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A Proteomic Platform to Identify Off-Target Proteins Associated with Therapeutic Modalities that Induce Protein Degradation or Gene SilencingDOI 10.1101/2020.11.18.389148
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