Article

Transcriptome-wide mapping reveals an RNA-dependent mechanism of platinum cancer drugs

2025-12-23

Abstract excerpt

Small molecules developed to target proteins or DNA may also bind RNA, but the extent and biological significance of such interactions among oncology drugs remain poorly defined. Here, we systematically profiled RNA interactions of a cohort of clinically approved anticancer agents and uncovered widespread RNA off-targeting. Cisplatin, a frontline chemotherapeutic agent for solid tumors, has emerged as a prominent...

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Literature Corpus work: 550c5dc5-3565-55d1-ad2a-a95038bc3fea
DOI: 10.64898/2025.12.20.694502

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