A Proteomic Platform to Identify Off-Target Proteins Associated with Therapeutic Modalities that Induce Protein Degradation or Gene Silencing

Abstract excerpt

Novel modalities such as Proteolysis Targeting Chimera (PROTAC) and RNA interference (RNAi) have the ability to inadvertently alter the abundance of endogenous proteins. Currently available in vitro secondary pharmacology assays, which evaluate off-target binding or activity of small molecules, do not fully assess the off-target effects of PROTAC and are not applicable to RNAi. To address this gap, we developed a...

Topics

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• Computational Drug Discovery Methods
• Drug Discovery
• Monoclonal and Polyclonal Antibodies Research
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• RNA and protein synthesis mechanisms
• Ubiquitin and proteasome pathways
• Viral Infectious Diseases and Gene Expression in Insects

Identifiers and source

Literature Corpus work

64a75f98-12bd-532b-8960-d58a0741bf0d

DOI

10.21203/rs.3.rs-296026/v1