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From single-omics to interactomics: How can ligand-induced perturbations modulate single-cell phenotypes?

Advances in protein chemistry and structural biology - 1 Jan 2022

Piochi L F, Gaspar A T, Rosário-Ferreira N, Preto A J, Moreira I S

Abstract excerpt

Cells suffer from perturbations by different stimuli, which, consequently, rise to individual alterations in their profile and function that may end up affecting the tissue as a whole. This is no different if we consider the effect of a therapeutic agent on a biological system. As cells are exposed to external ligands their profile can change at different single-omics levels. Detecting how these changes take...

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PMID: 35871896
DOI: 10.1016/bs.apcsb.2022.05.006

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