Article

SHIFTR enables the unbiased and multiplexed identification of proteins bound to specific RNA regions in live cells

2023-10-10

Abstract excerpt

<h4>ABSTRACT</h4> RNA-protein interactions determine the cellular fate of RNA and are central to regulating gene expression outcomes in health and disease. To date, no method exists that is able to identify proteins that interact with specific regions within endogenous RNAs in live cells. Here, we develop SHIFTR ( S elective RNase H -mediated interactome framing for target RNA regions), an efficient and scalabl...

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Literature Corpus work: e8d29bbb-b364-5ab9-9fff-da7775d5da28
DOI: 10.1101/2023.10.09.561498

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