Article

Transcriptome-wide mapping of small-molecule RNA-binding sites in live cells

2024-06-01

Abstract excerpt

Small molecules targeting RNA can be valuable chemical probes and potential therapeutics. The interactions between small molecules, particularly fragments, and RNA, however, can be difficult to detect due to their modest affinities and short residence times. Here, we describe the procedures for mapping the molecular fingerprints of small molecules in vitro and throughout the human transcriptome in live cells, iden...

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Literature Corpus work: 6f885747-5cfc-5bd1-a490-ff7e4d21f006
DOI: 10.1101/2024.05.30.596700

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