Article

Longitudinal and large-scale monitoring of transcriptome and RBP-RNA interactome in living cells by engineered protein nanocages

2025-03-26

Abstract excerpt

<title>Abstract</title> <p>Nondestructive sequencing of RNA from live cells is essential for monitoring and understanding dynamic biological processes. However, most existing RNA sequencing methods rely on cell lysis or fixation, limiting their applicability for longitudinal studies. Here, we introduce POND-seq (Protein nanocage-empOwered Non-Destructive sequencing), a novel approach that employs secretory protei...

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Literature Corpus work: 2879546b-38fb-5bdf-9b73-6feff305c61c
DOI: 10.21203/rs.3.rs-6053638/v1

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