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The spatiotemporal transcriptional profiling of murine brain during cerebral malaria progression and after artemisinin treatment

11 Feb 2025

Abstract excerpt

Cerebral malaria (CM) is a severe encephalopathy caused by Plasmodium parasite infection, resulting in thousands of annual deaths and neuro-cognitive sequelae even after anti-malarial drugs treatment. Despite efforts to dissect the mechanism, the cellular transcriptomic reprogramming within the spatial context remains elusive. Here, we constructed single-cell and spatial transcriptome atlases of experimental CM...

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PMID: 39934099
DOI: 10.1038/s41467-024-52223-7

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