Article

Febrile temperature enhances <i>Plasmodium falciparum</i> cytoadhesion by disrupting the endothelial glycocalyx

2025-09-08

Abstract excerpt

Fever, a universal host defense in infection and inflammation, paradoxically contributes to neurological complications in malaria. While febrile temperatures enhance the expression of parasite virulence proteins that mediate vascular adhesion and disease severity, its effects in the endothelium remain elusive. Here we present a 3D fever-on-a-chip model that recapitulates human brain and lung microvessels under feb...

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Literature Corpus work: 318aa2f3-6de0-59ed-be27-4dd58196ba92
DOI: 10.1101/2025.09.07.674757

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