Article

Mechanical confinement drives monocyte-to-macrophage differentiation

2026-04-01

Abstract excerpt

Cells in vivo experience mechanically diverse microenvironments in which physical confinement is a pervasive but poorly understood regulator of their behavior and fate. Whether and how mechanical confinement governs immune cell differentiation remains unknown. Here, we reveal that a mechanical cue — long-term confinement is sufficient to drive monocyte-to-macrophage differentiation through a mechanoepigenetic path...

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Literature Corpus work: 114b19fa-7a65-5441-a5f9-de0e75d9034a
DOI: 10.64898/2026.03.31.715742

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