Article

Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological response

2024-02-17

Abstract excerpt

<h4>Purpose: </h4> In many diseases, an overabundance of macrophages contributes to adverse outcomes. While numerous studies have compared macrophage phenotype after mechanical stimulation or with varying local stiffness, it is unclear if and how macrophages themselves contribute to mechanical forces in their microenvironment. <h4>Methods:</h4> Raw 264.7 murine macrophages were embedded in a confining agarose gel,...

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Literature Corpus work: 27fa19c9-43a5-54b6-8686-034334de9c02
DOI: 10.1101/2024.02.14.580327

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