Article

WASp activity in macrophages prevents mechano-induced inflammation by protecting the nuclear envelope

2024-12-23

Abstract excerpt

Mutations in the immune-specific actin regulator WASp induce a proinflammatory state in myeloid cells, whose underlying causes remain poorly defined. Here, we applied microfabricated tools that mimic tissue mechanical forces to explore the role of WASp in connecting mechano-sensing to the activation of inflammatory responses in macrophages. We show that WASp-deficient macrophages carry alterations in nuclear struc...

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Identifiers and source

Literature Corpus work: c34511f8-f62e-524c-ba6e-50b7842701a1
DOI: 10.1101/2024.12.23.630061

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