Article

Manipulation of the nucleoscaffold potentiates cellular reprogramming kinetics

2023-03-13

Abstract excerpt

Somatic cell fate is an outcome set by the activities of specific transcription factors and the chromatin landscape and is maintained by gene silencing of alternate cell fates through physical interactions with the nuclear scaffold. Here, we evaluate the role of the nuclear scaffold as a guardian of cell fate in human fibroblasts by comparing the effects of transient loss (knockdown) and mutation (progeria) of fun...

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Literature Corpus work: 01feed7e-a256-5ea2-952e-8e82cd65cd31
DOI: 10.1101/2023.03.12.532246

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