Article

Polarization Increases Nuclear Stiffness in Macrophages Despite Reduction in Lamin A/C Levels

2025-11-25

Abstract excerpt

Macrophages are innate immune cells contributing to tissue homeostasis and various pathologies. Signals from their environment can lead macrophages to adapt distinct functional phenotypes, a process called polarization. Because macrophages have been previously shown to degrade the nuclear envelope proteins lamin A/C upon pro-inflammatory polarization, and lamins are considered key determinants of nuclear deformabi...

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Literature Corpus work: 4d8cfe1f-38b0-5c8b-94a1-57ce4f318d4e
DOI: 10.1101/2025.11.22.689940

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