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Article

Constricted migration modulates stem cell differentiation

12 Jun 2019

Abstract excerpt

Tissue regeneration at an injured site depends on proliferation, migration, and differentiation of resident stem or progenitor cells, but solid tissues are often sufficiently dense and constricting that nuclei are highly stressed by migration. In this study, constricted migration of myoblastic cell types and mesenchymal stem cells (MSCs) increases nuclear rupture, increases DNA damage, and modulates...

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Identifiers

PMID: 31188712
DOI: 10.1091/mbc.e19-02-0090

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