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A high-resolution single-nucleus RNA sequencing reveals conserved macrophage activation trajectories across muscle regeneration and dystrophy.

2026-03-31

Abstract excerpt

<title>Abstract</title> <p>Macrophages are dominant leukocytes in skeletal muscle, yet their functional heterogeneity, particularly in muscular dystrophies, remains poorly defined. To reconcile this, we generated a high-resolution single-nucleus RNA sequencing (snRNA-seq) atlas of skeletal muscle. By bypassing dissociation-induced stress, we achieved superior resolution over standard single-cell clustering, captu...

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Literature Corpus work
989caf2a-d267-5705-8c39-f5eb89fdb8d4
DOI
10.21203/rs.3.rs-9129034/v1
Open publication

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A high-resolution single-nucleus RNA sequencing reveals conserved macrophage activation trajectories across muscle regeneration and dystrophy.DOI 10.21203/rs.3.rs-9129034/v1
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