Article

Polygenic prediction of human longevity on the supposition of pervasive pleiotropy

2023-12-11

Abstract excerpt

<h4>ABSTRACT</h4> The highly polygenic nature of human longevity renders cross-trait pleiotropy an indispensable feature of its genetic architecture. Leveraging the genetic correlation between the aging-related traits (ARTs), we sought to model the additive variance in lifespan as a function of cumulative liability from pleiotropic segregating variants. We tracked allele frequency changes as a function of viabilit...

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Literature Corpus work: 114a5c42-a5c6-5486-ac72-4e5a86951ea6
DOI: 10.1101/2023.12.10.23299795

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