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Article

Genetic geroscience and Alzheimer's disease: The pleiotropy is the point!

Journal of Alzheimer's disease : JAD - 1 Apr 2025

Shardell Michelle, Chen Chixiang

Abstract excerpt

Geroscience aims to understand how the biology of aging serves as a shared contributor to multiple age-related health conditions. Genetic variants that influence multiple traits are said to exert pleiotropic effects. The study by Pan and colleagues applied a modern statistical model to identify genetic variants with potentially pleiotropic effects by assessing their joint association with Alzheimer's disease and...

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PMID: 40026006
DOI: 10.1177/13872877251321182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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