Article
Heritability of and mortality prediction with a longevity phenotype: the healthy aging index.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Apr 2014
Sanders Jason L, Minster Ryan L, Barmada M Michael, Matteini Amy M, Boudreau Robert M, Christensen Kaare, Mayeux Richard, Borecki Ingrid B, Zhang Qunyuan, Perls Thomas, Newman Anne B
Abstract excerpt
BACKGROUND: Longevity-associated genes may modulate risk for age-related diseases and survival. The Healthy Aging Index (HAI) may be a subphenotype of longevity, which can be constructed in many studies for genetic analysis. We investigated the HAI's association with survival in the Cardiovascular Health Study and heritability in the Long Life Family Study. METHODS: The HAI includes systolic blood pressure,...
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