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Article

The association of a polygenic lifespan score with the risk of common age-related diseases and mortality.

The journals of gerontology. Series A, Biological sciences and medical sciences - 23 Aug 2025

Tynkkynen Niko Paavo, Koivunen Kaisa, Herranen Päivi, Joensuu Laura, Törmäkangas Timo, Sillanpää Elina, FinnGen

Abstract excerpt

BACKGROUND: Aging increases the risk of major noncommunicable diseases. Research into the genetics of health-related traits could reveal genetic pathways for robustness against these diseases. We studied how a genetic predisposition for a long lifespan is associated with the risk of all-cause mortality and major age-related noncommunicable diseases. METHODS: We analyzed data from 376 753 participants (mean...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40680229
DOI: 10.1093/gerona/glaf156
PMCID: PMC12380463

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