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Article

Polygenic prediction of human longevity on the supposition of pervasive pleiotropy.

Scientific reports - 28 Aug 2024

Jabalameli M Reza, Lin Jhih-Rong, Zhang Quanwei, Wang Zhen, Mitra Joydeep, Nguyen Nha, Gao Tina, Khusidman Mark, Sathyan Sanish, Atzmon Gil, Milman Sofiya, Vijg Jan, Barzilai Nir, Zhang Zhengdong D

Abstract excerpt

The highly polygenic nature of human longevity renders pleiotropy an indispensable feature of its genetic architecture. Leveraging the genetic correlation between aging-related traits (ARTs), we aimed to model the additive variance in lifespan as a function of the cumulative liability from pleiotropic segregating variants. We tracked allele frequency changes as a function of viability across different age bins...

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PMID: 39198552
DOI: 10.1038/s41598-024-69069-0
PMCID: PMC11358495

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