Article

A distinctive tumor compartment in pancreatic lobules defined by nascent stroma and classical tumor cell phenotype

2024-03-15

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor type characterized by a particularly extensive stroma. While different types of cancer-associated fibroblasts (CAFs) in this desmoplastic stroma have been described, areas of early invasion and nascent stroma are understudied. Here, we identify a distinctive PDAC niche within the pancreatic lobules, a compartment dominated by pancreatic exocrine...

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Literature Corpus work: 113d8bf1-5ff8-53b9-8565-cacd6098a6fc
DOI: 10.1101/2024.03.14.584614

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