Article

TRANSCRIPTOMIC ANALYSIS OF THE RELATIONSHIP BETWEEN PANCREATIC DUCTAL ADENOCARCINOMA STROMAL SUBTYPES AND NEURAL INVASION

2025-01-19

Abstract excerpt

We investigated the association between pancreatic ductal adenocarcinoma (PDAC) subtypes and neural invasion (NI) status in order to assess what factors influence the inter-tumor heterogeneity of NI. We built single-sample classifiers for prominent subtype schemes using multiple approaches. We predicted the subtype labels of samples with known NI status using the classifiers based on pairwise gene expression compa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 05cbacf4-42c6-59ec-98e8-6ed89bad133b
DOI: 10.1101/2025.01.13.632859

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TRANSCRIPTOMIC ANALYSIS OF THE RELATIONSHIP BETWEEN PANCREATIC DUCTAL ADENOCARCINOMA STROMAL SUBTYPES AND NEURAL INVASIONDOI 10.1101/2025.01.13.632859Read

Invasion status stratifies the composition of the human pancreatic cancer perineural nicheSemantic proximity Read

Integrating multi-modal transcriptomics identifies cellular subtypes with distinct roles in PDAC progressionSemantic proximity Read

Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancerSemantic proximity Read

A distinctive tumor compartment in pancreatic lobules defined by nascent stroma and classical tumor cell phenotypeSemantic proximity Read

Integrating multi-modal transcriptomics identifies cellular subtypes with distinct roles in PDAC progressionSemantic proximity Read

Gene expression profiling of 1200 pancreatic ductal adenocarcinoma reveals novel subtypesSemantic proximity Read

Unsupervised class discovery in pancreatic ductal adenocarcinoma reveals cell-intrinsic mesenchymal features and high concordance between existing classification systemsSemantic proximity Read

Single-cell and spatially resolved atlas of pancreatic cancer reveals immunophenotypes associated with clinical outcomeSemantic proximity Read

Coordinated single-cell tumor microenvironment dynamics reinforce pancreatic cancer subtypeSemantic proximity Read

The Limits of Molecular Signatures for Pancreatic Ductal Adenocarcinoma SubtypingSemantic proximity Read

Transcriptional deconvolution reveals consistent functional subtypes of pancreatic cancer epithelium and stromaSemantic proximity Read

Spatial Transcriptomics of IPMN Reveals Divergent Indolent and Malignant LineagesSemantic proximity Read