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Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic Resistance

21 Sept 2022

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment with remarkable cellular and spatial heterogeneity that meaningfully impacts disease biology and treatment resistance. Recent advances in tissue imaging capabilities, single-cell analytics, and disease modeling have shed light on organizing principles that shape the stromal complexity of PDAC tumors. These insights into the...

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PMID: 36130070
DOI: 10.1146/annurev-pathmechdis-031621-024600

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