Article
Single cell transcriptome analysis of human pancreas reveals transcriptional signatures of aging and somatic mutation patterns
2017-02-13
Abstract excerpt
As organisms age, cells accumulate genetic and epigenetic changes that eventually lead to impaired organ function or catastrophic transformation such as cancer. Since aging appears to be a stochastic process of increasing disorder 1 cells in an organ will be individually affected in different ways - thus rendering bulk analyses of postmitotic adult tissues difficult to characterize. Here we directly measure the e...
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Identifiers and source
- Literature Corpus work
- 23e12bf2-67a6-541c-9baa-06ad1cd04463
- DOI
- 10.1101/108043