Article

Genetic determinants of gene expression noise and its role in complex trait variation

2024-12-01

Abstract excerpt

<h4>ABSTRACT</h4> Even genetically identical cells in a homogeneous environment can exhibit heterogeneous mRNA abundance because of widely unavoidable random fluctuations, typically referred to as ‘gene expression noise’. Recent studies showed that noise, not just a nuisance, is indeed involved in cellular activities (e.g., immune response), evolutionary processes, and diseases mechanisms. However, determinants of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 25d63f0a-8495-5599-9591-652a2d846bdd
DOI: 10.1101/2024.11.29.24318180

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic determinants of gene expression noise and its role in complex trait variationDOI 10.1101/2024.11.29.24318180Read

Genetic determinants of gene expression noise and its role in complex trait variation.Semantic proximity Read

Genetic variants associated with cell-type-specific intra-individual gene expression variability reveal new mechanisms of genome regulationSemantic proximity Read

Impact of rare and common genetic variation on cell type-specific gene expression in human bloodSemantic proximity Read

Aging causes changes in transcriptional noise across a diverse set of cell typesSemantic proximity Read

Controlled Noise: Evidence of Epigenetic Regulation of Single-Cell Expression VariabilitySemantic proximity Read

Estimating the <i>cis</i> -heritability of gene expression using single cell expression profiles controls false positive rate of eGene detectionSemantic proximity Read

Genome-wide identification and characterization of QTLs for transcriptional noise in human midbrain cellsSemantic proximity Read

Single-Cell Genomics Elucidates Molecular Variations and Regulatory Mechanisms in Circulating Immune CellsSemantic proximity Read

The Genetic Architecture of Gene Expression in Peripheral Blood.Semantic proximity Read

Characterizing the landscape of gene expression variance in humansSemantic proximity Read

Characterizing the landscape of gene expression variance in humans.Semantic proximity Read

Genetics of human gene expression.Semantic proximity Read