Article
Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns.
Cell - 5 Oct 2017
Enge Martin, Arda H Efsun, Mignardi Marco, Beausang John, Bottino Rita, Kim Seung K, Quake Stephen R
Abstract excerpt
As organisms age, cells accumulate genetic and epigenetic errors that eventually lead to impaired organ function or catastrophic transformation such as cancer. Because aging reflects a stochastic process of increasing disorder, cells in an organ will be individually affected in different ways, thus rendering bulk analyses of postmitotic adult cells difficult to interpret. Here, we directly measure the effects of...
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