Article
Genetic determinants of gene expression noise and its role in complex trait variation.
Cell reports - 23 Dec 2025
Long Yuexuan, Ni Xiaolin, Chen Tingwei, Huang Xianzhe, Hong Qiyang, Wang Jixin, Wang Cong, Huang Zigeng, Xu Haiqing, Sun Mengyi, Pang Junling, Choi Jiyeon, Zhang Tongwu, Long Erping
Abstract excerpt
Even genetically identical cells in homogeneous environments exhibit heterogeneous mRNA abundance, typically called "gene expression noise," which is involved in key cellular activities, evolutionary processes, and disease mechanisms. However, determinants of the gene expression noise and its functional role in variations of human complex traits remain largely unexplored. Here, we established an atlas of gene...
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