Article

MECOM promotes leukemia progression and inhibits mast cell differentiation through functional competition with GATA2

2024-05-20

Abstract excerpt

<h4>ABSTRACT</h4> MECOM is a nuclear transcription factor essential for the proliferation of hematopoietic stem cells (HSCs) and myeloid leukemia cells. MECOM contains N- and C-terminal zinc finger domains (ZFDs) and binding motifs for the corepressor CtBP to regulate gene expression. Recent studies have shown that germline MECOM variants are associated with thrombocytopenia, radioulnar synostosis, and bone marr...

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Literature Corpus work: 10f81544-804a-5edf-9e54-f7941afd2134
DOI: 10.1101/2024.05.20.594903

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