SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub.

doi:10.1038/s41467-018-04462-8

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Article

SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub.

Nature communications - 6 Jun 2018

Piazza Rocco, Magistroni Vera, Redaelli Sara, Mauri Mario, Massimino Luca, Sessa Alessandro, Peronaci Marco, Lalowski Maciej, Soliymani Rabah, Mezzatesta Caterina, Pirola Alessandra, Banfi Federica, Rubio Alicia, Rea Delphine, Stagno Fabio, Usala Emilio, Martino Bruno, Campiotti Leonardo, Merli Michele, Passamonti Francesco, Onida Francesco, Morotti Alessandro, Pavesi Francesca, Bregni Marco, Broccoli Vania, Baumann Marc, Gambacorti-Passerini Carlo

Abstract excerpt

SETBP1 variants occur as somatic mutations in several hematological malignancies such as atypical chronic myeloid leukemia and as de novo germline mutations in the Schinzel-Giedion syndrome. Here we show that SETBP1 binds to gDNA in AT-rich promoter regions, causing activation of gene expression through recruitment of a HCF1/KMT2A/PHF8 epigenetic complex. Deletion of two AT-hooks abrogates the binding of SETBP1...

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Identifiers

PMID: 29875417
DOI: 10.1038/s41467-018-04462-8
PMCID: PMC5989213

Genes

SETBP1
MECOM
PHF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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