Article

MECOM promotes leukemia progression and inhibits mast cell differentiation through functional competition with GATA2

2024-06-25

Abstract excerpt

<title>Abstract</title> <p> MECOM is a nuclear transcription factor essential for the proliferation of hematopoietic stem cells (HSCs) and myeloid leukemia cells. MECOM contains N- and C-terminal zinc finger domains (ZFDs) and binding motifs for the corepressor CtBP to regulate gene expression. Recent studies have shown that germline <italic>MECOM</italic> variants are associated with thrombocytopenia, radioul...

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Literature Corpus work: 4d4fa44d-54be-526c-b779-101d55c1978b
DOI: 10.21203/rs.3.rs-4521321/v1

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