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Article

Loss of c-Kit and bone marrow failure upon conditional removal of the GATA-2 C-terminal zinc finger domain in adult mice.

European journal of haematology - 1 Sept 2016

Li Haiyan S, Jin Jin, Liang Xiaoxuan, Matatall Katie A, Ma Ying, Zhang Huiyuan, Ullrich Stephen E, King Katherine Y, Sun Shao-Cong, Watowich Stephanie S

Abstract excerpt

Heterozygous mutations in the transcriptional regulator GATA-2 associate with multilineage immunodeficiency, myelodysplastic syndrome (MDS), and acute myeloid leukemia (AML). The majority of these mutations localize in the zinc finger (ZnF) domains, which mediate GATA-2 DNA binding. Deregulated hematopoiesis with GATA-2 mutation frequently develops in adulthood, yet GATA-2 function in the bone marrow remains...

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Source

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Identifiers

PMID: 26660446
DOI: 10.1111/ejh.12719
PMCID: PMC5680037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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