GATA2 deficiency and related myeloid neoplasms.

doi:10.1053/j.seminhematol.2017.05.002

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Article

GATA2 deficiency and related myeloid neoplasms.

Seminars in hematology - 1 Apr 2017

Wlodarski Marcin W, Collin Matthew, Horwitz Marshall S

Abstract excerpt

The GATA2 gene codes for a hematopoietic transcription factor that through its two zinc fingers (ZF) can occupy GATA-DNA motifs in a countless number of genes. It is crucial for the proliferation and maintenance of hematopoietic stem cells. During the past 5 years, germline heterozygous mutations in GATA2 were reported in several hundred patients with various phenotypes ranging from mild cytopenia to severe...

Topics

GATA2 Transcription Factor
Genetic Predisposition to Disease
Hematologic Neoplasms
Humans
Myeloproliferative Disorders

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Identifiers

PMID: 28637621
DOI: 10.1053/j.seminhematol.2017.05.002
PMCID: PMC5650112

Genes

GATA2
ASXL1
SETBP1

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