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Article

MECOM promotes leukemia progression and inhibits mast cell differentiation through functional competition with GATA2.

Leukemia - 1 Jul 2026

Iida Kohei, Nakanishi Mayuko, Nakahara Jakushin, Asada Shuhei, Isobe Tomoya, Yabushita Tomohiro, Fukushima Tsuyoshi, Tanaka Yosuke, Ozawa Manabu, Yamada Yasuhiro, Kitamura Toshio, Yamamoto Keita, Goyama Susumu

Abstract excerpt

MECOM is a transcription factor critical for the maintenance of hematopoietic stem cells (HSCs) and the pathogenesis of myeloid leukemia. Germline mutations clustered in the C-terminal zinc finger domain (ZFD) of MECOM are known to cause MECOM-associated syndromes, involving bone marrow failure and skeletal anomalies. However, the molecular consequences of these mutations and the precise downstream mechanisms of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42086934
DOI: 10.1038/s41375-026-02977-4
PMCID: PMC13323086

Genes

MECOM
GATA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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