Article
GATA2 is required for lymphatic vessel valve development and maintenance.
The Journal of clinical investigation - 3 Aug 2015
Kazenwadel Jan, Betterman Kelly L, Chong Chan-Eng, Stokes Philippa H, Lee Young K, Secker Genevieve A, Agalarov Yan, Demir Cansaran Saygili, Lawrence David M, Sutton Drew L, Tabruyn Sebastien P, Miura Naoyuki, Salminen Marjo, Petrova Tatiana V, Matthews Jacqueline M, Hahn Christopher N, Scott Hamish S, Harvey Natasha L
Abstract excerpt
Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been shown to underlie a range of clinical phenotypes, including Emberger syndrome, a disorder characterized by lymphedema and predisposition to myelodysplastic syndrome/acute myeloid leukemia (MDS/AML). Despite well-defined roles in hematopoiesis, the functions of GATA2 in the lymphatic vasculature and the mechanisms by...
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