GATA2 mutations in myeloid malignancies: Two zinc fingers in many pies.

doi:10.1002/iub.2204

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Article

GATA2 mutations in myeloid malignancies: Two zinc fingers in many pies.

IUBMB life - 1 Jan 2020

Leubolt Georg, Redondo Monte Enric, Greif Philipp A

Abstract excerpt

The GATA family of transcription factors are zinc finger (ZF) DNA-binding proteins that regulate transcription during development and cell differentiation. GATA2 plays an essential role in the regulation of hematopoiesis. As a result, mutations in this gene or alterations in its expression level or function have been linked to a variety of human hematologic disorders. In this review, we summarize the findings and...

Topics

Animals
Cell Differentiation
GATA2 Transcription Factor
Humans
Mutation
Myelodysplastic Syndromes
Zinc Fingers

Source

Open in PubMed

Identifiers

PMID: 31785092
DOI: 10.1002/iub.2204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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