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Metabolic reprogramming by ex vivo glutamine inhibition endows CAR-T cells with less-differentiated phenotype and persistent antitumor activity.

Cancer letters - 10 Jul 2022

Shen Luyan, Xiao Yefei, Zhang Chaoting, Li Shance, Teng Xia, Cui Likun, Liu Ting, Wu Nan, Lu Zheming

Abstract excerpt

The inadequate in vivo persistence of chimeric antigen receptor (CAR)-modified T cells has been shown to lead to poor therapeutic efficacy and disease recurrence. In vivo persistence is associated with the differentiation subsets infused, with less differentiated TN or TCM conferring superior renewal capacity and antitumor immunity compared to TEM or TEFF. However, ex vivo expanded CAR-T cells exhibit phenotypic...

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Identifiers

PMID: 35489446
DOI: 10.1016/j.canlet.2022.215710

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