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The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores.

Communications biology - 2 Sept 2022

Page Madeline L, Vance Elizabeth L, Cloward Matthew E, Ringger Ed, Dayton Louisa, Ebbert Mark T W, Miller Justin B, Kauwe John S K

Abstract excerpt

The process of identifying suitable genome-wide association (GWA) studies and formatting the data to calculate multiple polygenic risk scores on a single genome can be laborious. Here, we present a centralized polygenic risk score calculator currently containing over 250,000 genetic variant associations from the NHGRI-EBI GWAS Catalog for users to easily calculate sample-specific polygenic risk scores with...

Topics

Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Knowledge Bases
Multifactorial Inheritance
Polymorphism, Single Nucleotide
Risk Factors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36056235
DOI: 10.1038/s42003-022-03795-x
PMCID: PMC9438378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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