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Article

A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts.

Biological psychiatry - 1 Nov 2021

Ni Guiyan, Zeng Jian, Revez Joana A, Wang Ying, Zheng Zhili, Ge Tian, Restuadi Restuadi, Kiewa Jacqueline, Nyholt Dale R, Coleman Jonathan R I, Smoller Jordan W, Yang Jian, Visscher Peter M, Wray Naomi R

Abstract excerpt

BACKGROUND: Polygenic scores (PGSs), which assess the genetic risk of individuals for a disease, are calculated as a weighted count of risk alleles identified in genome-wide association studies. PGS methods differ in which DNA variants are included and the weights assigned to them; some require an independent tuning sample to help inform these choices. PGSs are evaluated in independent target cohorts with known...

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Identifiers

PMID: 34304866
DOI: 10.1016/j.biopsych.2021.04.018
PMCID: PMC8500913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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