Article

ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer’s disease

2023-03-21

Abstract excerpt

ZCCHC17 is a putative master regulator of synaptic gene dysfunction in Alzheimer’s Disease (AD), and ZCCHC17 protein declines early in AD brain tissue, before significant gliosis or neuronal loss. Here, we investigate the function of ZCCHC17 and its role in AD pathogenesis. Co-immunoprecipitation of ZCCHC17 followed by mass spectrometry analysis in human iPSC-derived neurons reveals that ZCCHC17’s binding partners...

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Literature Corpus work: 0fa13a65-4f84-56ee-8d1e-6c317d647c67
DOI: 10.1101/2023.03.21.533654

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