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Article

NPTX2-Centered Cognitive Resilience Mechanisms in the Context of AD Pathology

2025-10-20

Abstract excerpt

<h4>Background</h4> Cognitive resilience to Alzheimer’s disease (AD) pathology is associated with preserved expression of NPTX2, an activity-regulated synaptic protein involved in circuit plasticity, excitation–inhibition balance, and complement-linked synapse regulation. However, the broader molecular programs coordinated with NPTX2 in resilient individuals remain unclear. <h4>Methods</h4> We analyzed postmorte...

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Literature Corpus work
f872459c-e7da-5997-9cc4-4b75c2042a8e
DOI
10.1101/2025.10.17.683150
Open publication

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NPTX2-Centered Cognitive Resilience Mechanisms in the Context of AD PathologyDOI 10.1101/2025.10.17.683150
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